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Timing and Frequency Considerations: AOD-9604 is most commonly administered once daily in the morning on an empty stomach to maximize absorption and align with natural circadian metabolic rhythms

doi: 10.3892/mmr.2016.5551 126 QiuSChenJQinTHuYWangDFanQet al

In one study, adjusted odds ratios for MASLD demonstrated a clear gradient: lowest in never smokers, higher in exclusive cigarette smokers, and highest among dual users, suggesting an additive or even synergistic effect of combined exposure [140]